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KMID : 0356620150300010110
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Journal of Korean Society of Endocrinology
2015 Volume.30 No. 1 p.110 ~ p.115
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Multiple Myeloma in a Patient with Acromegaly
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:Kang Yu-Mi
:Choi Jong-Han/:Lee Min-Jung/:Ahn A-Ri/:Park Chan-Jeoung/:Chang Ki-Ju/:Seo Se-young/:Hong Sun-In/:Kim Min-Seon
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Abstract
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Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1 (IGF-1) is known to influence tumor formation by increasing cell proliferation and inhibiting apoptosis. Multiple myeloma (MM) is a plasma cell neoplasm, and previous studies have suggested the possible role of IGF-1 in its development of MM. However, no cases of acromegaly accompanied with MM have been reported in Asia to date. We here report the case of a 58-year-old woman with acromegaly accompanied with MM who presented with longstanding acromegalic manifestations resulting from a GH-secreting pituitary adenoma and also exhibited anemia, a reversed albumin/globulin ratio, and plasmacytosis on bone marrow examination. Because IGF-1 has been suggested to play an important role in the development and progression of MM, the patient promptly underwent surgical removal of the pituitary adenoma via a transsphenoidal approach. Since there is currently no consensus on therapeutic guidelines and suggested prognosis for MM with acromegaly, long-term follow-up of such cases is needed.
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KEYWORD
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Acromegaly, Multiple myeloma, Insulin-like growth factor I
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